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Ruben Amorim has made eight changes from their 1-1 draw at Fulham on Sunday.
Benjamin Šeško makes his first start for Manchester United, while Kobbie Mainoo lines up in midfield, with André Onana in goal.
Mainoo has not come off the bench in their first two league games, and Onana also makes his first appearance of the season.
Matheus Cunha, Patrick Dorgu and Amad Diallo are the three players who keep their places from the weekend.
Diego León is on the bench for the first time this season since joining from Cerro Porteño.
Man Utd: Onana; Fredricson, Maguire, Heaven; Dalot, Ugarte, Mainoo, Dorgu; Amad, Šeško, Cunha.
Subs: Bayındır, Heaton, De Ligt, León, Casemiro, Fernandes, Mount, Mbeumo, Zirkzee.
Grimsby Town vs Man Utd: Starting XIs for Carabao Cup clash
